Alpha Synuclein S129A Mutant Pre-formed Fibrils

Synonyms

Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson's disease familial 1 Protein, Alpha Synuclein S129A

Background

Elevated levels of phosphoserine 129 (pS129) on alpha-synuclein have long been considered a hallmark of Parkinson’s disease and other synucleinopathies, where up to 90% of alpha-synuclein deposition in Lewy Bodies contains pS129, compared to ≤4% in normal brains. Further, pS129 was recently shown to function as a physiological regulator of neuronal activity. Alpha-synuclein S129A monomers and fibrils cannot be phosphorylated at position 129 and therefore can be utilized to study phospho-S129-independent biology and pathology. Further, this material can be used to confirm the induction of endogenous pS129 pathology in disease models.

Description

Human Recombinant Alpha Synuclein S129A Mutant Pre-formed Fibrils

SWISS

P37840-1

Amino Acid Sequence

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPAEEGYQDYEPEA

Protein Length

Full length (1 - 140 aa)

Applications

WB, SDS PAGE, In vitro assay

Research Areas

Alzheimer's Disease, Neurodegeneration, Neuroscience, Parkinson's Disease, Synuclein, Tangles & Tau, Multiple System Atrophy

Concentration

Lot/batch specific. See included datasheet.

Nature

Recombinant

Storage Buffer

1X PBS pH 7.4

Purity

>95%

Purification

Ion-exchange Purified

Storage

Stored at -80°C

Shipping

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

Notes

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Species	Human
Tag	Tag Free
Expression Systems	E.coli
Keywords	Preformed fibrils