CSPG4,NG2 Polyclonal Antibody

Product Information

It targets CSPG4, NG2 in WB, IHC, FC, ELISA applications and shows reactivity with human, mouse, rat samples.

Background Information

CSPG4, also named as HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16 and NG2, is a proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. CSPG4 may inhibit neurite outgrowth and growth cone collapse during axon regeneration. It is cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. CSPG4 may regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. It modulates the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. CSPG4 functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. It promotes retraction fiber formation and cell polarization through Rho GTPase activation and stimulates alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. CSPG4 activates FAK and ERK1/ERK2 signaling cascades. The antibody is specific to CSPG4.

Full Name

Chondroitin sulfate proteoglycan 4

Synonyms

CSPG4, CSPG4,NG2, HMW MAA, MCSP, MCSPG, MEL CSPG, MSK16, Neuron-glia 2, NG2

Tested Reactivity

Human, mouse, rat

Cited Reactivity

Human, mouse, rat

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Calculated Molecular Weight

251 kDa

Observed Molecular Weight

240-250 kDa, 450kDa

Gene ID

1464

GenBank Accession Number

NM_001897

Gene Symbol

CSPG4

Form

Liquid

Purification Method

Antigen affinity purification

Storage Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage Conditions

Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.

Positive WB Detected

A375 cells

Target	CSPG4
Cell Type	Oligodendrocytes
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, FC, ELISA
Reactivity	Human, Mouse, Rat
Conjugate	Unconjugated
Keywords	Oligodendrocytes; Rabbit; IgG; WB, IHC, FC, ELISA