CXCR4 Monoclonal Antibody

Product Information

It targets CXCR4 in WB, IHC, IF, FC, CoIP, ELISA applications and shows reactivity with human, mouse samples.

Background Information

C-X-C chemokine receptor type 4 (CXCR4) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609). CXCR4 has a calculated molecular weight of 40 kDa. In addition to the predicted species of 45-47 kDa for glycosylated CXCR4 monomers, due to ubiquitination, dimeration, and different degrees of glycosylation, additional species can also exist and have been reported in some researches, including 67 kDa (PMID: 23917520), 55, 67, 87 kDa (PMID: 20028517), 80 kDa (PMID: 10506573), 47, 50, 62, and 98 kDa (PMID: 16204649).

Synonyms

CD184, CXC R4, CXCR 4, CXCR4, CXCR4B, D2S201E, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, LESTR, SDF 1 receptor, WHIM

Full Name

Chemokine (C-X-C motif) receptor 4

Tested Reactivity

Human, mouse

Cited Reactivity

Human, mouse

Class

Monoclonal

Type

Antibody

Immunogen

CXCR4 fusion protein

Calculated Molecular Weight

352 aa, 40 kDa

Observed Molecular Weight

60~70 kDa

Gene ID

7852

GenBank Accession Number

BC020968

Gene Symbol

CXCR4

Form

Liquid

Purification Method

Caprylic acid/ammonium sulfate precipitation

Storage Buffer

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage Conditions

Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.

Positive WB Detected

HeLa cells, K-562 cells, Daudi cells, Ramos cells, Jurkat cells, U-937 cells, THP-1 cells

Positive IHC Detected

Human tonsillitis tissue, mouse brain tissue, human prostate cancer tissue, human breast cancer tissue, mouse spleen tissue

Positive FC Detected

Jurkat cells

Target	CXCR4
Cell Type	NSCs
Host	Mouse
Isotype	IgM
Applications	WB, IHC, IF, FC, CoIP, ELISA
Reactivity	Human, mouse
Conjugate	Unconjugated
Keywords	NSCs; Mouse; IgM; WB, IHC, IF, FC, CoIP, ELISA