EOMES/TBR2 Polyclonal Antibody

Product Information

It targets EOMES/TBR2 in WB, ELISA applications and shows reactivity with Human, Mouse, rat samples.

Background Information

EOMES/TRB2 (also named Eomesodermin/Tbr2) encode T-box transcription factor expressed highly in the intermediate progenitor stage of the developing neuron. During migration of the neurons, radial glia divide and migrate towards the surface of the cerebral cortex, there are three stages of cellular development: radial glia, intermediate progenitors, and postmitotic projection neurons. Radial glia express Pax6, while intermediate progenitor cells express Eomesodermin/Tbr2, and postmitotic projection neurons express Tbr1 (PMID:15634788; PMID:16320258). This process also called neurogenesis, and demonstrated that Eomesodermin/Tbr2 has been implicated in neurodevelopment. According to the mouse model, several articles showed that EOMES/TRB2 KO mice having proliferating cells decreased and having smaller upper cortical layers and a smaller sub ventricular zone in the brain (PMID:18940588). What's more, Eomesodermin/Tbr2 has also been found participating in immune response (PMID:20713880).

Synonyms

EOMES, Eomesodermin homolog, T box brain protein 2, T brain 2, TBR 2, TBR2

Full Name

Eomesodermin homolog (Xenopus laevis)

Tested Reactivity

Human, mouse, rat

Class

Polyclonal

Type

Antibody

Immunogen

EOMES/TBR2 fusion protein

Calculated Molecular Weight

73 aa

Observed Molecular Weight

70-72 kDa

Gene ID

8320

GenBank Accession Number

NM_001278182

Gene Symbol

EOMES

Form

Liquid

Purification Method

Antigen affinity purification

Storage Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage Conditions

Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.

Positive WB Detected

Mouse brain tissue

Target	EOMES/TBR2
Cell Type	Intermediate progenitors
Host	Rabbit
Isotype	IgG
Applications	WB,ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	Intermediate progenitors; Rabbit; IgG; WB,ELISA