GAD65 Polyclonal Antibody

Product Information

It targets GAD65 in WB, IP, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Background Information

GAD2, also named as GAD65, belongs to the group II decarboxylase family. GAD2 catalyzes the production of GABA. It is responsible for the synthesis of the essential neurotransmitter gamma-aminobutyric acid (GABA) from L-glutamic acid. GAD2 is expressed in nervous and endocrine systems and are thought to be involved in synaptic transmission and INS secretion. Autoantibodies against GAD2 may serve as markers for type I diabetes. Many individuals suffering from an adult onset disorder known as Stiff Person Syndrome (SPS) also express autoantibodies to GAD2. The antibody is specific to GAD2.

Synonyms

GAD 65, GAD2, GAD65, Glutamate decarboxylase 2

Full Name

Glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)

Tested Reactivity

Human, mouse, rat

Type

Antibody

Class

Polyclonal

Immunogen

Peptide

Calculated Molecular Weight

65 kDa

Observed Molecular Weight

65 kDa

GenBank Accession Number

NM_000818

Gene ID

2572

Gene Symbol

GAD2

Form

Liquid

Purification Method

Antigen affinity purification

Storage Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage Conditions

Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.

Positive WB Detected

Mouse brain tissue, rat brain tissue

Positive IP Detected

Mouse brain tissue

Positive IF Detected

HeLa cells

Target	GAD65
Cell Type	GABAergic neurons
Host	Rabbit
Isotype	IgG
Applications	WB, IP, IHC, IF, ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	GABAergic neurons; Rabbit; IgG; WB, IP, IHC, IF, ELISA