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Human Alpha-Synuclein Pre-formed Fibrils Protein, His Tag (ThT active)

CAT#: PFF-S003

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Overview Specification

Species	Human
Tag	His
Expression Systems	E.coli
Keywords	Preformed fibrils

Synonyms	SNCA, NACP, PARK1, alpha-Synuclein
Background	Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at the presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Description	Human Alpha-Synuclein Pre-formed Fibrils
SWISS	P37840-1
Theoretical Molecular Weight	16.3 kDa
Formulation	Supplied as 0.2 μm filtered solution in PBS, pH 7.4.
Molecular Characterization	This protein carries a polyhistidine tag at the C-terminus.
Endotoxin	Less than 1.0 EU per μg by the LAL method.
Purity	>90% as determined by SDS-PAGE.
Storage	Please avoid repeated freeze-thaw cycles. The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C; The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions; The sonicated fibril should be stored at -70°C for not more than 8 weeks.
Shipping	This product is supplied and shipped with dry ice, please inquire the shipping cost.
Notes	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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