CAT#: PFF-S004
Species | Human |
Tag | Tag Free |
Expression Systems | E.coli |
Keywords | Preformed fibrils |
Synonyms | NACP, PARK1, PARK4, PD1 |
Background | Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at the presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration. |
Description | Human Alpha-Synuclein Pre-formed Fibrils |
SWISS | P37840-1 |
Theoretical Molecular Weight | 14.5 kDa |
Formulation | Supplied as 0.2 μm filtered solution in PBS, pH 7.4. |
Molecular Characterization | This protein carries no "tag". |
Endotoxin | Less than 1.0 EU per μg by the LAL method. |
Purity | >90% as determined by SDS-PAGE. |
Storage | Please avoid repeated freeze-thaw cycles. The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C; The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions; The sonicated fibril should be stored at -70°C for not more than 8 weeks. |
Shipping | This product is supplied and shipped with dry ice, please inquire the shipping cost. |
Notes | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |