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Human Alpha-Synuclein Protein, Fc Tag (MALS verified)

CAT#: IVD-P005

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Overview Specification

Species	Human
Tag	Fc
Expression Systems	HEK293 cell
Keywords	In vitro diagnostic proteins

Synonyms	SNCA, NACP, PARK1, alpha-Synuclein
Background	Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SREs (Soluble NSF Attachment Protein REceptors) at the presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.
Source	Human Alpha-Synuclein
SWISS	P37840-1
Theoretical Molecular Weight	40.9 kDa
Formulation	Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Reconstitution	Please see Certificate of Analysis for specific instructions. For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
Molecular Characterization	This protein carries a human IgG1 Fc tag at the C-terminus. The protein migrates as 47-52 kDa and 53-56 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	Less than 1.0 EU per μg by the LAL method.
Purity	> 95% as determined by SDS-PAGE. > 90% as determined by SEC-MALS.
Storage	For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Notes	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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