Human Tau-441 / 2N4R Pre-formed Fibrils Protein, Tag Free (ThT active)

Synonyms	DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU
Background	Tau is a microtubule-associated protein, which is encoded by the MAPT gene located on chromosome 17q21. Tau Promotes microtubule assembly and stability and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.
Description	Human Tau-441 Pre-formed Fibrils
SWISS	P10636-8
Theoretical Molecular Weight	45.8 kDa
Formulation	Supplied as 0.2 μm filtered solution in 50 mM Tris, 150 mM NaCl, 1 mM DTT, 1 mM EDTA, pH 7.5.
Molecular Characterization	This protein carries no "tag".
Endotoxin	Less than 1.0 EU per μg by the LAL method.
Purity	>95% as determined by SDS-PAGE.
Storage	Please avoid repeated freeze-thaw cycles. This product is stable after storage at: The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Shipping	This product is supplied and shipped with dry ice, please inquire the shipping cost.
Notes	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.