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Human Tau-441 K18 Pre-formed Fibrils Protein, His Tag (ThT active)

CAT#: PFF-S002

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Overview Specification

Species	Human
Tag	His
Expression Systems	E.coli
Keywords	Preformed fibrils

Synonyms	DDPAC, FTDP-17, MAPT, MSTD, MTBT1, Tau, PHF-tau, TAU
Background	Tau is a microtubule-associated protein, which is encoded by the MAPT gene located on chromosome 17q21. Tau Promotes microtubule assembly and stability and might be involved in the establishment and maintenance of neuronal polarity. Hyperphosphorylation of the tau protein (tau inclusions, pTau) can result in the self-assembly of tangles of paired helical filaments and straight filaments, which are involved in the pathogenesis of Alzheimer's disease, frontotemporal dementia, and other tauopathies.
Description	Human Tau-441 K18 Pre-formed Fibrils Protein
SWISS	P10636-8
Theoretical Molecular Weight	13.8 kDa
Formulation	Supplied as 0.2 μm filtered solution in PBS, pH 7.4.
Molecular Characterization	This protein carries a polyhistidine tag at the N-terminus.
Endotoxin	Less than 0.05 EU per μg by the LAL method.
Purity	>90% as determined by SDS-PAGE.
Storage	Please avoid repeated freeze-thaw cycles. The product should be stored at -70°C or room temperature for short storage. Do not store fibrils on ice or at 4°C; The unsonicated fibril is validated to be stable after storage at -70°C for 1 year under sterile conditions; The sonicated fibril should be stored at -70°C for not more than 8 weeks.
Shipping	This product is supplied and shipped with dry ice, please inquire the shipping cost.
Notes	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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