MOG Polyclonal Antibody - Alfa Cytology

Product Information

It targets MOG in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Background Information

Myelin/oligodendrocyte glycoprotein (MOG), a 23-28 kDa glycoprotein, a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. Its presence on the outer- most lamellae of mature CNS myelin and its late appearance during myelinogenesis suggest that it contributes to myelin maturation or maintenance. 10 isoforms of MOG produced by alternative splicing have been described, and heterodimers may be formed between the different isoforms. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7), a neurological disabling sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Role of MOG in the pathogenesis of multiple sclerosis (MS) has been reported but remains to be clarified.

Full Name

Myelin oligodendrocyte glycoprotein

Synonyms

MOG, MOGIG 2, myelin oligodendrocyte glycoprotein

Tested Reactivity

Human, mouse, rat

Cited Reactivity

Human, mouse

Class

Polyclonal

Type

Antibody

Immunogen

MOG fusion protein

Calculated Molecular Weight

295 aa, 34 kDa

Observed Molecular Weight

25-28 kDa

Gene ID

4340

GenBank Accession Number

BC035938

Gene Symbol

MOG

Form

Liquid

Purification Method

Antigen affinity purification

Storage Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage Conditions

Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.

Positive WB Detected

Mouse brain tissue, rat brain tissue

Positive IHC Detected

Mouse brain tissue

Target	MOG
Cell Type	Oligodendrocytes
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, IF, ELISA
Reactivity	Human, Mouse, Rat
Conjugate	Unconjugated
Keywords	Oligodendrocytes; Rabbit; IgG; WB, IHC, IF, ELISA