Nurr1/NR4A2 Polyclonal Antibody

Product Information

It targets Nurr1/NR4A2 in WB, IHC, IF, ChIP, ELISA applications and shows reactivity with human samples.

Background Information

NR4A2 belongs to the orphan nuclear receptor (NR) family referred to as NR4A family, which have been implicated in cell cycle regulation, apoptosis, inflammation, metabolism and more recently in carcinogenesis [PMID:22583411]. NR4A2 also has a role in the expression of several proteins that are necessary for the synthesis and regulation of DA, such as tyrosine hidroxilase, DA transporter, vesicular monoamine transporter 2, and cRET [PMID:22294735]. Act as a transcriptional regulator, NR4A2 is essential for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons [PMID: 17184956].

Synonyms

HZF 3, NOT, NR4A2, NURR1, Nurr1/NR4A2, Orphan nuclear receptor NURR1, RNR1, TINUR

Full Name

Nuclear receptor subfamily 4, group A, member 2

Tested Reactivity

Human

Type

Antibody

Class

Polyclonal

Immunogen

Nurr1/NR4A2 fusion protein

Calculated Molecular Weight

66 kDa

Observed Molecular Weight

66 kDa

GenBank Accession Number

BC009288

Gene ID

4929

Gene Symbol

NR4A2

Form

Liquid

Purification Method

Antigen affinity purification

Storage Buffer

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage Conditions

Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20°C storage.

Positive WB Detected

A431 cells, fetal human brain tissue, SH-SY5Y cells, COLO 320 cells

Positive IHC Detected

Human gliomas tissue

Positive IF Detected

HepG2 cells

Target	Nurr1/NR4A2
Cell Type	Dopaminergic neurons
Host	Rabbit
Isotype	IgG
Applications	WB, IHC, IF, ChIP, ELISA
Reactivity	Human, mouse, rat
Conjugate	Unconjugated
Keywords	Dopaminergic neurons; Rabbit; IgG; WB, IHC, IF, ChIP, ELISA