Logo
Contact Us
Banner

Carbidopa monohydrate

Products

Quote Request

Carbidopa monohydrate

Carbidopa monohydrate

Catalog No.: PC0038

Size: 5 mg,10 mg, 25 mg,50 mg, 100 mg, 200 mg, 500 mg

Description

Carbidopa ((S)-(-)-carbidopa) monohydrate is a peripheral decarboxylase inhibitor used in the study of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cells and tumor growth.

Molecular Weight 244.24
Formula C10H16N2O5
CAS No. 38821-49-7
Appearance Solid
Color White to off-white
SMILES OC1=C(O)C=CC(C[C@](C)(NN)C(O)=O)=C1.O
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191.
Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC50=29 μM).
In Vivo Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

Logo

As the scientific machine continues to turn, Alfa Cytology is committed to keeping pace. We continue to expand our services and improve our existing resources to help our customers accelerate their research and support their careers.

Company
Our Services
Our Products

Copyright © Alfa Cytology. All rights reserved.