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PROTAC BRD4 Degrader-6

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PROTAC BRD4 Degrader-6

PROTAC BRD4 Degrader-6

Catalog No.: PC0040

Size: 50 mg, 100mg, 250mg

Description

PROTAC BRD4 Degrader-6 (Compound 32a) is a potent small molecule BRD4 degrader with an IC50 of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 efficiently degrades BRD4 protein and inhibits c-Myc expression. PROTAC BRD4 Degrader-6 inhibits proliferation and induces apoptosis in the pancreatic cancer cell line BxPC3. PROTAC BRD4 Degrader-6 can be used in human pancreatic cancer research.

Molecular Weight 926.9
Formula C43H40F2N10O10S
CAS No. 2410947-56-5
SMILES O=C(C(N1)=CC(C(C2=CC(NS(=O)(CC)=O)=CC=C2OC3=CC=C(F)C=C3F)=CN4C)=C1C4=O)NCC5=CN(CCOCC(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)N=N5
Shipping Room temperature in continental US; may vary elsewhere.
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
In Vitro PROTAC BRD4 Degrader-6 (compound 32a) (72 hours; BxPC3 cell) has anti-proliferation activity with IC50 value of 0.165 μM.
PROTAC BRD4 Degrader-6 (compound 32a) (1 μM; 48 hours; BxPC3 cell) induces BRD4 protein degradation in a time-dependent manner, which results in the continuous decrease of c-Myc expression.
PROTAC BRD4 Degrader-6 (compound 32a) (1 μM; 48 hours; BxPC3 cell) induces the cell cycle arrest and apoptosis.
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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