CFPAC-1

Description

CFPAC-1 is a ductal pancreatic adenocarcinoma that was generated by differential trypsin digestion of explant cultures of liver metastatic lesions in a 26-year-old white man with cystic fibrosis (CF). This cell line expresses cystic fibrosis transmembrane regulator (CFTR) and has ion transport properties consistent with CF deficiency. CFPAC-1 cells display epithelial morphology and polarization, with apical microvilli. Expression of cytokeratin and carcinoembryonic antigen characteristic of pancreatic duct cells has been described. These cells express the CF gene and display the most common CF mutation, a deletion of three nucleotides resulting in the deletion of phenylalanine 508. CFPAC-1 cells are also tumorigenic in nude mice.