PSN1

Description

Human pancreatic cancer cell line PSN1 was derived from pancreatic adenocarcinoma tissue. After transplantation into nude mice, a PSN1 cell line was established from the xenografts. What is unique about PSN1 cells is the extent of amplification of c-myc (50-fold) and activated c-Ki-ras (3-6-fold) with a point mutation from GGT to CGT at codon 12 Same as PSN1 cells. Primitive tumors and contained increased amounts of c-myc and c-Ki-ras transcripts. Loss of one of the two p53 alleles and a point mutation from AAG to CAG at codon 132 in the remaining allele were also observed in PSN1.