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RIN-m

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RIN-m

Catalog No.: PC0017

Description

Established from transplantable pancreatic tumors in the islets of Langerhans. The tumor originated in irradiated NEDH-suppressed albino rats and was maintained by serial transplantation of Nedh rats. The cell line RIN-m was established from the fourth nude mouse xenograft after transplantation into athymic nude mice, and 9 days after tumor resection, the cells were exposed to cystine-free medium, resulting in complete elimination of fibroblasts. RIN-m cells secrete insulin and somatostatin. High levels of levodopa decarboxylase and membrane-bound secretory granules were detected. RIN-5F (95090402) was established as a secondary clone of RIN-m.

Origin Rat islet cell tumour
Application Study of biology of pancreatic islet cells, synthesis, storage and secretion of insulin and somatostatin
Biological Source Rat pancreas
Growth Mode Adherent
Karyotype Not specified
Morphology Epithelial-like
Products Somatostatin, insulin
Receptors Not specified
Technique Cell culture, suitable for mammals.
Relevant Disease Cancer
Shipped In Dry ice
Culture Medium RPMI 1640 + 2mM Glutamine + 10% Foetal Bovine Serum (FBS).
All of our services are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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