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Liver Cancer

Liver cancer, specifically hepatocellular carcinoma (HCC), is the sixth most common cancer worldwide and the third leading cause of cancer death worldwide. Alfa Cytology is a world leader in the development of cancer vaccines. With our extensive experience and advanced platform, we are confident we can provide the best vaccine development services for liver cancer.

Introduction to Liver Cancer

The main risk factors for liver cancer are hepatitis B and C virus (HBV and HCV) infection. Non-viral causes include alcoholism and aflatoxin. HCC is the most common primary liver malignancy, accounting for approximately 6% of all newly diagnosed cancer cases globally. The overall prognosis for HCC patients is poor, with 5-6% survival at 5 years.

TAA or Epitope of Liver Cancer

Cancer vaccines based on tumor-associated antigen (TAA) can initiate a powerful anti-tumor immune response through antigen-presenting cells such as dendritic cells (DC) and macrophages, showing great potential in cancer prevention and therapy. The number of commonly used liver cancer TAAs is limited and can be divided into the following categories.

Cancer/Testicular (CT) Antigens

  • MAGE-A
  • SSX-2
  • NY-ESO-1

Widespread Overexpressed Antigens

  • Telomerase Reverse Transcriptase (TERT)
  • Wilms' Tumor 1 (WT-1)

Oncofetal Antigen

  • Alfa-fetoprotein (AFP)
  • Glypican 3 (GPC3)

Multiple Types of Liver Cancer Vaccine

Initiating or enhancing the body's immune response against cancer is the main goal of cancer immunization strategies. Suppression of T cells during tumor microenvironment homeostasis and reduced influx of T cells into tumor invasion reduce the effectiveness of some immunotherapies. The following table shows some commonly used vaccine types classified according to different standards.

Types of Vector

Types of Vaccine

Phase of Cancer

  • Preventive Tumor Targeting Vaccines
  • Therapeutic Tumor Targeting Vaccines

Our Service

Nowadays, there are trials of immunotherapy based on a variety of strategies, but the effective results are very limited. To improve these conditions, Alfa Cytology provides a variety of services related to liver cancer vaccine development by addressing specific constraints.

To develop a more effective liver cancer vaccine, it is necessary to identify new and more specific TAAs, tumor-specific antigens (TSAs), or epitopes designed to induce specific CD4+ and CD8+ T cell activation. To achieve this, Alfa Cytology provides the following related antigen identification services.

In Silico Prediction TAA/TSA Identification
  • High Throughput Technique
  • Genomic Analysis
  • Immunoinformatics Algorithm
  • Transcriptome Analysis
  • High-Resolution Mass Spectrometry (MS)
  • TILs-based Identification

The Process of Liver Cancer Vaccine Development

Identification of novel specific tumor epitopes for liver cancer Peptides Proteins DNA RNA DC ... Vaccine strategies Combinatorial strategies Adjuvants Delivery Systems Improved efficacy of liver cancer vaccine

Developing innovative and more effective cancer vaccines remains at the forefront of cancer immunotherapy. Personalized and combination therapies will play a crucial role in enhancing the efficacy of cancer vaccines. Alfa Cytology is committed to the research and development of cancer vaccines, from the discovery of cancer antigens, and the development of different types of vaccines, to vaccine research for different cancer types, providing one-stop services. If you are interested in our service, please contact us.

 For Research Only.