Non-Hodgkin Lymphoma (NHL)
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Non-Hodgkin Lymphoma (NHL)

Non-Hodgkin lymphoma (NHL) is a malignant lymphoma arising from lymphocytes in the lymphatic system. Primarily manifesting as lymph node enlargements or solid tumor formations. As the prevalent aggressive lymphoma, conventional radiotherapy entails notable side effects, urging the pursuit of novel preventive and therapeutic interventions. Alfa Cytology, a proficient cancer vaccine development service provider, pledges safe and dependable vaccines for non-Hodgkin's lymphoma.

Introduction to Non-Hodgkin Lymphoma

Non-Hodgkin's lymphoma predominantly arises within lymph nodes and lymphoid tissues, with potential involvement in organs such as the stomach, intestines, or skin. In certain instances, it extends to the bone marrow and bloodstream, constituting a subtype of blood cancer. NHL distinguishes itself from Hodgkin's lymphoma by the absence of Reed-Sternberg cells characteristic of the former. NHL encompasses a heterogeneous array of disorders, categorized based on several criteria such as pathologic attributes, molecular genetics, clinical manifestation, and prognosis. The principal classifications of the NHL are as follows.

  • B-cell non-Hodgkin's lymphoma (B-cell NHL)
    A malignancy originating from B-lymphocytes, it comprises diverse subtypes including diffuse large B-cell lymphoma, marginal zone B-cell lymphoma, lymphoblastoid lymphoma, and synovial zone lymphoma.
  • T-cell and natural killer cell non-Hodgkin's lymphoma (T/NK-cell NHL)
    This category comprises malignant lymphomas arising from T cells or natural killer cells, including peripheral T-cell lymphoma, cutaneous T-cell lymphoma, Nasal-type/peripheral T-cell lymphoma, mesenteric T-cell lymphoma, and NK/T-cell lymphoma.
  • Lymphoblastic lymphoma
    Lymphoblastic lymphoma, derived from immature lymphocytes called lymphoblasts, typically manifests in young individuals, particularly children, and adolescents. It encompasses various subtypes, such as B-cell lymphoblastic lymphoma and T-cell lymphoblastic lymphoma.

Therapy and Vaccine Development for Non-Hodgkin Lymphoma

In non-Hodgkin's lymphoma, the bulk of cases arise from mature B lymphocytes, with a smaller subset originating from T lymphocytes or natural killer cells. This form of lymphoma is more prevalent in immunocompromised individuals, such as those with HIV/AIDS or organ transplants. Immunotherapy-based approaches, including bispecific antibodies, immune checkpoint inhibitors, and genetically engineered T cells carrying chimeric antigen receptors, alone or in combination with therapeutic monoclonal antibodies, immunomodulators, chemotherapy, or targeted agents, have shown unprecedented activity in heavily treated NHL patients. While no lymphoma vaccine has yet gained approval, ongoing research primarily focuses on indolent lymphomas, with an exploration into other types of NHL underway.

Fig.2 Overview of immunotherapy approaches in non-Hodgkin lymphomas.Fig.1 Overview of immunotherapy approaches in non-Hodgkin lymphomas. (Pytlik, R., et al., 2020)

Our Service

Given the slow progression of indolent NHL and its typically asymptomatic nature, current research primarily aims at devising non-chemotherapy interventions. This includes a strong emphasis on advancing cancer vaccines to manage lymphoma effectively while also mitigating or eradicating the adverse effects associated with conventional treatments. Alfa Cytology is committed to driving innovation in the field of cancer vaccines and providing high-quality cancer vaccines that can be used for non-Hodgkin's Lymphoma.

NHL Vaccine Research Services

Protein-based Vaccines A potential therapeutic approach aimed at using specific proteins overexpressed on the surface of lymphoma cells as targets to stimulate the immune system to attack and remove tumor cells. Several such vaccines for inert NHL are now in clinical studies.
Nucleic acid-based Vaccines Utilizing nucleic acid molecules like DNA or RNA to encode lymphoma-specific antigens triggers the body's immune response, enabling recognition and elimination of tumor cells, thus eradicating abnormal cells.
Cell-based Vaccines A cell-based cancer vaccine is under development for treating indolent NHL, merging the body's tumor cells with cytokines to bolster the immune response, thereby synergistically suppressing the progression of non-Hodgkin's lymphoma.

One Step Vaccine Development Services

Alfa Cytology can support you in the development of a vaccine for non-Hodgkin's lymphoma in many ways, including the following services.

With our expert scientific team, Alfa Cytology provides various adjuvants and delivery systems options, aiding in the development of a tailored non-Hodgkin's lymphoma cancer vaccine aligned with your research requirements and your research endeavors. If you're interested in our Non-Hodgkin's Lymphoma Vaccine R&D services or any related inquiries, please don't hesitate to contact us. We eagerly await the opportunity to collaborate with you.


  1. Pytlik, R.,et al.; (2020). Current Immunotherapy Approaches in Non-Hodgkin Lymphomas. Vaccines, 8(4), 708.
 For Research Only.