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Lymphoma and Leukemia

Fig.1 Non-Hodgkin Lymphoma (NHL).

Lymphoma and leukemia are blood diseases resulting from irregular white blood cell growth or function. They impact the immune system and can have severe effects. Alfa Cytology stands out as a premier provider of cancer vaccine services worldwide. With our wealth of experience and state-of-the-art platforms, we deliver unmatched vaccine development services tailored for lymphoma and leukemia.

Introduction to Lymphoma and Leukemia

Leukemia and lymphoma are both cancers that originate in blood cells. And these cancers have similar cellular origins.

Leukemia

Leukemia, a form of cancer predominantly affecting the blood and bone marrow, originates from bone marrow cells transforming leukemic cells. Following this alteration, these leukemic cells gain a proliferative and survival advantage over healthy cells, leading to aberrant cell growth and compromised bone marrow function.

Lymphoma

Lymphoma, similar to leukemia, manifests as malignant tumors originating within the lymphatic system. It commonly develops from lymphocytes located in lymphoid tissues such as lymph nodes, spleen, and bone marrow. This condition represents an abnormal proliferation of cells within the lymphatic network, leading to tumor formation and systemic complications.

Therapy And Vaccine Development for Lymphoma and Leukemia

Hematologic malignancies originate in lymphoid organs, where immune cells develop. The notable efficacy of immunotherapy in addressing solid tumors has catalyzed inquiries into its viability for hematologic malignancies. Immunotherapies for leukemia and lymphoma mainly encompass CAR-T cell therapy and monoclonal antibody therapy.

CAR-T cell therapy - modifies a patient's T cells to identify and destroy cancer cells, exemplified by Kymriah for acute lymphoblastic leukemia (ALL) and large B-cell lymphoma (DLBCL).

Monoclonal antibody therapies - mark cancer cells for immune destruction by targeting specific antigens, like Rituximab targeting CD20 in B-cell lymphoma.

Additionally, vaccine therapies, designed to prompt the immune system to attack cancer cells, are under clinical investigation. These insights hold promise for the development of precise and efficacious immunotherapeutic modalities tailored to the distinctive characteristics of individual hematologic malignancies.

Fig.2 Overview of immunotherapy approaches in non-Hodgkin lymphomas.Fig.1 Unique and shared mechanisms of immune evasion in leukemia and lymphoma. (Curran, E. K., et al.,2017)

Our Service

The degree of severity of lymphoma and leukemia is evident in its effects on the immune system and the complexities of therapy. Timely diagnosis and intervention are imperative for addressing these conditions effectively. Alfa Cytology provides tailored cancer vaccine development services, allowing for the creation of vaccines targeting a wide range of lymphomas and leukemias.

Alfa Cytology is committed to addressing hurdles in every facet of lymphoma and leukemia vaccine advancement, boasting proficiency in cancer antigen forecasting, cancer antigen detection, and preliminary vaccine investigations. Contact us for further details on our services.

Reference

  1. Curran, E. K., et al.; (2017). Mechanisms of Immune Tolerance in Leukemia and Lymphoma. Trends in immunology, 38(7), 513-525. https://doi.org/10.1016/j.it.2017.04.004
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