Genomics Analysis for Brain Tumors

Brain tumors with different sites of origin, cell types, and mutations may exhibit different patterns. These factors can also affect the treatment outcome of brain tumors. For example, gliomas are classified into four grades and various types, which have different degrees of malignancy and vary greatly in the prognosis of conventional radiotherapy. The molecular mechanisms underlying the development of primary and recurrent gliomas also differ among the different staging as well as the molecular mechanisms underlying the development of recurrent gliomas. Therefore, new staging criteria for molecular pathology are urgently needed to guide clinical treatment and individualized medical therapy to improve the survival and quality of life of brain tumor patients.

We provide genomic analysis services for brain tumors

Previously, brain tumor diagnosis was made by comparing cancer cells with normal cells through traditional microscopy, but a new and more accurate diagnosis comes from genomic profiling. Genomic profiling plays a key role in the diagnosis and grading of brain tumors. Alfa Cytology offers brain tumor genomic analysis services to our clients to identify DNA alterations that drive tumor growth and discover genetic changes in specific genes.

We use high-throughput whole genome sequencing and next-generation microarray capture sequencing methods that allow an analysis of copy number changes and base modifications in many previously characterized brain tumor samples. We can reveal comprehensive information about the entire genome of brain tumors, including mutations in coding and non-coding regions. We can detect all types of mutations in tumors, including structural and copy number variants.

The general analysis flow

Optional analysis contents

Advantages of our technology

• Copy number variations and epigenetic profiles at the chromosomal arm level can be detected.
• Comprehensive and cost-effective identification of genetic changes in brain cancer samples, including analysis of copy number (CN) changes epigenetic base modifications, and single nucleotide variants (SNVs).
• Methylation data can be obtained directly from the same genome-wide dataset.
• Reveals virtually all potentially oncogenic chromosomal translocations and the gene deletions and mutations that lead to the development of specific types of brain tumors.
• Billions of different DNA fragments can be read simultaneously by next-generation sequencing technology.
• The genetic material is analyzed more than one billion times to ensure high sensitivity and accuracy of the results.

The wealth of data results provided by Alfa Cytology allows you to develop a holistic picture of commonalities, personalities, and novel insights across the brain tumor spectrum. to identify novel genetic risk factors for brain tumors, reveal specific differences in individual DNA that increase susceptibility to brain tumors, and also provide clinicians with a new way to be able to differentiate between brain tumor types. Please contact our staff to learn how we can provide you with brain tumor genomic analysis services.