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In the natural course of malignant tumors, brain metastasis occurs in about 20-40% of patients. Metastasis of tumor cells is one of the most important features of malignant tumors, and the intra- and intercellular molecular mechanisms involved in the metastatic process are very complex. Alfa Cytology focuses on tumor cells undergoing epithelial-mesenchymal transition, circulating tumor cells surviving in blood vessels, tumor cell dormancy, tumor cell heterogeneity, and its stemness during brain metastasis to help you study a series of events related to tumor microenvironments such as tumor cell-stromal cell interaction and tumor-associated blood vessel formation.
Figure 1. Steps in the development of brain metastases in an animal model. (Steeg, P. S., et al., 2011)
Whether this process occurs in the early stage of tumorigenesis, in the primary site, in the metastatic site, or during metastasis, the aim is to better adapt to the microenvironment of the distant organ. This change can be expressed at the DNA level or the epigenetic level, thus influencing the phenotypic changes of the tumor cells. We can help you interpret the biology of brain metastatic tumor cells in terms of genetic alterations, post-translational modifications, and metabolic characteristics.
Genomic alterations such as single nucleotide variation (SNV), copy number variation (CNV), deletion, amplification, etc. have been demonstrated between the genome of metastatic brain lesions and the primary lesions, and these genomic alterations mainly involve the activation of multiple cell signaling pathways, apoptosis, and cell adhesion and other functions. We will help you find this genetic alteration and assist you to study this series of alteration patterns and their generation mechanisms to help explain the mechanism of tumor brain metastasis formation, and also provide promising therapeutic targets for brain metastasis foci treatment.
Alfa Cytology provides you with research support and more information on many of the above brain metastases, offering a series of solutions for targeted drug development, molecular mechanism research, and in vitro model building for brain metastases tumors. Please feel free to contact us to submit your requirements for earlier communication of project details.
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