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The main goal of functional genomics is the identification of gene products as well as possible therapeutic targets. It does not provide diagnostic markers for endpoints and ultimate diagnostic information as reflected by biochemical alterations in the disease. Metabolomics is a complement to genomics and proteomics, and can more sensitively identify specific metabotypes arising from genetic alterations associated with brain tumors, disease, and environmental factors.
Tumor metabolism and its interactions with the tumor microenvironment is an active area of research. Metabolic analysis can provide information on metabolic reprogramming at specific stages of tumor initiation and development. Alfa Cytology provides metabolomics analysis services for brain tumors to our clients. We apply techniques such as nuclear magnetic resonance and mass spectrometry to detect metabolite changes in various brain tumor tissues to help you study various metabolite molecules and their functions. This helps discover clusters of metabolomic markers in the early stages of brain tumorigenesis and provides insight into the molecular mechanisms of brain tumorigenesis.
| Category | Details |
| Brain tumor-associated metabolic markers | In the early stages of tumorigenesis, we can use metabolomics technologies to monitor changes or fluctuations of metabolites in specific metabolic processes. To predict the progression of brain tumors or to monitor the response of brain tumors to intervention. We also combine the quantitative analysis of metabolomics techniques with advanced statistical analysis methods, allowing us to obtain a characteristic metabolic profile of early changes in brain tumors. This allows you to assess the molecular etiology of established brain tumors by changes in specific metabolites, identify metabolite changes in response to biological effects, and assist in characterizing brain tumor susceptibility. |
| Brain tumor diagnosis | As brain tumors cause pathophysiological changes in the body, there are corresponding changes in the metabolites of the body. We can perform a metabolomic analysis of these metabolites, which will help you better understand the pathological process and the metabolic pathways of substances in the body. This will lead to the discovery of brain tumor-related biomarkers and assist in clinical diagnosis. |
| Brain tumor treatment, prognosis assessment | By analyzing the kinetics of drug metabolism and the endogenous metabolite changes caused by drugs, we can provide you with a systematic and holistic understanding of the changes in the metabolic profile of the body, which can be used to individualize the treatment for the heterogeneity of brain tumors and the individual differences of patients. It can guide the dosage of anti-brain tumor drugs and evaluate the effectiveness and safety of treatment. |
In addition to our regular metabolomic analysis services, we also offer spatial metabolomics analysis. We have further upgraded desorption electrospray ionization mass spectrometry imaging (DESI-MSI) technology into air flow-assisted ionization mass spectrometry imaging (AFAI-MSI) technology. The charged droplets in the transport tube are further desolvated, enriched, and ionized under the action of high-speed airflow and voltage, and then the detection sensitivity is improved by using air flow and transport tubes for long-distance transport of charged droplets.
Metabolic reprogramming of tumor cells is one of the most prominent features in the development of brain tumors, while the study of molecular mechanisms of brain tumor metabolism and targeting brain tumor metabolic pathways has become a hot topic in the field of oncology research. Alfa Cytology is dedicated to uncovering the functions and molecular mechanisms of metabolites, key enzymes, and key transporter proteins during brain tumor development using metabolomics analysis. It provides new avenues for early diagnosis and individualized treatment of malignant brain tumors. Please contact our staff to develop a protocol for you.
Brain Tumors
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