Methylation Sequencing for Brain Tumors

DNA methylation is a central part of epigenetics and is essential for normal cell function maintenance, embryonic development, and other life processes. disorders of DNA methylation are closely related to tumorigenesis and metastasis, also in brain tumors. Therefore, performing genome-wide DNA methylation detection and analysis is important for exploring the mechanisms of brain tumor development, metastasis, and recurrence as well as developing new anti-brain tumor strategies.

Our single-cell sequencing services for brain tumors

DNA methylation signature-based analysis has become one of the important approaches in brain tumor research. Alfa Cytology provides customers with methylation sequencing services to obtain not only methylation information of brain tumors but also copy number variants (amplifications, deletions, gene fusions, etc.). We also support co-application with other standard techniques such as histology, making DNA methylation analysis an effective adjunct to brain tumor classification, especially for poorly characterized and rare brain tumor types and subtypes.

• Accurately obtain genome-wide methylation C sites.
• Achieve precise and efficient localization of methylation sites with single-base resolution.
• Comprehensively analyze the effects of different treatments on genome-wide methylation levels and quickly and accurately find differentially methylated regions.
• Based on tumor tissue DNA methylation sequencing data, it helps you distinguish between nearly 100 different brain tumors.
• Detects early brain tumors and provides information about the tissue origin and even histological subtypes of brain tumors.

The categories of technologies we offer to detect DNA methylation

Basic services flow

Data analysis content

Sample types: DNA, blood, plasma/serum, tissue, cells, FFPE.

Our advantages

• Reliable library quality. We have rich experience in sample processing and library building due to many years of library technology accumulation.
• Complete quality control process. We can provide a complete set of quality control analyses to ensure data accuracy.
• Extensive basic analysis content. We can analyze methylation sequencing data from all levels.
• More personalized bioinformatics services. We have a mature bioinformatics team, familiar with various analysis algorithms and software. We fully interact with our customers to provide more personalized analysis ideas and analysis solutions.
• Highly readable data reports. We provide multifaceted data and graphical content and also write detailed manuals to help clients better view the data on their own.

Alfa Cytology offers DNA methylation sequencing services for brain tumors to help you gain a comprehensive understanding of the differences in genomic methylation levels in cancer and paraneoplastic cells. This is important for studying the molecular mechanisms of brain tumorigenesis and for finding molecular markers for early brain tumor diagnosis. Please contact our staff for the latest protocols.