What We Offer
Our nanomedicine characterization service delivers a full suite of physicochemical and biological quality attributes for nanoparticle-based drug delivery systems. We leverage industry-standard analytical techniques including dynamic light scattering (DLS), transmission electron microscopy (TEM), high-performance liquid chromatography (HPLC), and UV/Vis spectrophotometry to quantify particle size, polydispersity, zeta potential, morphology, encapsulation efficiency, drug loading, and in vitro release kinetics under physiologically relevant conditions.
We serve nanomedicine companies, drug formulation teams, and academic laboratories developing lipid nanoparticles, polymeric nanoparticles, liposomes, and nanosuspensions. Each project is scoped to the specific carrier type and payload, with quality-controlled documentation and a certificate of analysis delivered at project end. Our analytical team works closely with clients to align testing protocols with regulatory expectations for preclinical and early clinical development.
Our Analytical Suite
Particle Size and Zeta Potential
Determination of mean particle diameter, polydispersity index, and surface charge by DLS and electrophoretic light scattering, with results reported per batch and per accelerated stability time point.
Encapsulation Efficiency and Drug Loading
Quantification of encapsulated payload versus free payload using HPLC or UV/Vis methods after separation by ultrafiltration or size-exclusion chromatography, with mass balance confirmation.
In Vitro Release and Stability Profiling
Release kinetics in relevant biorelevant media (PBS, simulated gastric fluid) using dialysis or direct sampling methods, alongside storage stability (4°C, 25°C, 40°C) and freeze-thaw cycle testing.
How It Works
Project Deliverables
| Deliverable | Description |
|---|---|
| Particle Size Report | Mean hydrodynamic diameter, polydispersity index, and size distribution histogram from DLS analysis. |
| Zeta Potential Report | Electrophoretic mobility and zeta potential values measured at specified pH and buffer conditions. |
| Morphology Images | Representative transmission electron microscopy (TEM) or scanning electron microscopy (SEM) images with scale bars and qualitative description. |
| Encapsulation Efficiency Data | Percent encapsulation efficiency and drug loading (w/w) determined by validated HPLC or UV/Vis method. |
| In Vitro Release Profile | Cumulative release curve over time with sampling points, release medium composition, and temperature. |
Why Choose Our Service
Broad Platform Coverage
Our analytical suite is validated for lipid nanoparticles, polymeric nanoparticles, liposomes, nanosuspensions, and metal nanoparticles. Testing protocols are adaptable to diverse payloads including small molecules, nucleic acids, peptides, and proteins.
quality-controlled Documentation
All characterization reports include full method descriptions, raw data, and certificates of analysis compliant with ICH Q2(R1) and GMP Annex 1 standards, supporting regulatory submissions and investigator brochures.
Experienced Scientific Team
Our analytical scientists bring over a decade of combined experience in nanomedicine characterization, with deep expertise in method development, method qualification, and troubleshooting complex nanoparticle formulations.
Integrated Analytical Services
Beyond physicochemical testing, we offer complementary services including sterility and endotoxin testing, bioanalysis, and CMC regulatory support, allowing seamless integration under a single project manager.
References
Further Reading
Analytical characterization of liposomes and other lipid nanoparticles for drug delivery
View articleReady to Characterize Your Nanomedicine?
Contact our analytical team to discuss your nanoparticle characterization needs. We will provide a project-specific scope and timeline tailored to your formulation and development stage.