General Information
| Alternative Names | CLEC13D; C-type lectin domain family 13 member D; Macrophage mannose receptor 1-like protein 1; C-type lectin domain family 13 member D-like; MMR; CLEC13DL; CD206; Macrophage mannose receptor 1; bA541I19.1; CD antigen CD206; MRC1L1 |
| Target Name | CD206/MMR |
| Description | Mouse monoclonal antibody recognizes CD206 / MMR |
| Species Reactivity | Hu, Ms |
| Host | Mouse |
| Host Clonality | Mouse mAb |
| Clone | Monoclonal |
| Clone Number | 15-2 |
| Isotope | IgG1 |
| Antigen Species | Human |
| Antigen | Purified human mannose receptor (NP_002429.1) |
| Conjugate | Un-conjugated |
| Specificity | This antibody recognizes an extracellular epitope of CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes. |
| Application | CyTOF®-candidate, FACS, FuncSt, ICC/IF, IHC-Fr, IP, WB |
| Package | 100 μL |
| Form | Liquid |
| Purification | Purification with protein A. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Storage | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For research use only. Not intended for any clinical use. |
Application Suggestions
| Recommended Dilution for WB | Assay-dependent |
| Recommended Dilution for IHC-Fr | 1:25 |
| Recommended Dilution for IF | Assay-dependent |
| Recommended Dilution for IP | Assay-dependent |
| Recommended Dilution for ICC | Assay-dependent |
| Recommended Dilution for FACS | 1 - 4 µg/mL |
| Recommended Dilution for CyTOF®-candidate | Assay-dependent |
| Application Notes | IHC-Fr: Incubate with the antibody at 4°C for overnight. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Bioinformation
| Gene Name | MRC1 |
| Gene Full Name | Mannose receptor, C type 1 |
| Background | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. CD206 / MMR is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. |
| Biological Functions | CD206 / MMR mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E. (Microbial infection) Interacts with Hepatitis B virus envelope protein. [UniProt] |
| Research Field | Immune system antibody; M1/M2/TAM marker antibody; Macrophage marker antibody; M2 Macrophage marker antibody |
| Predict Molecular Weight | 166 kDa |
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
Copyright © Alfa Cytology. All rights reserved. Cookie Policy | Privacy Policy