Solutions for the Interaction of Immune Cells and Tumor Cells
Relying on the technology platform of the tumor microenvironment center, Alfa Oncology provides comprehensive solutions the study of the interactions between tumor cells and immune cells, helping researchers to successfully achieve their research goals.
The tumor microenvironment is a bidirectional, dynamic, and intricate network of interactions between mesenchymal tissue cells and tumor cells. Therefore, a full understanding of the tumor biology and molecular mechanisms that determine tumorigenesis and malignant progression requires careful study of each specific cell type within the tumor microenvironment. Tumor-infiltrating immune inflammatory cells play an important role in tumorigenesis and malignant progression. Once recruited into the tumor microenvironment, these cells can promote the cancer cell phenotype toward malignancy. In addition, they establish a complex network of intercellular interactions that help enhance and maintain the immunosuppressive microenvironment and promote immune escape, which ultimately promotes tumor progression.
Tumor formation is the management operation of the immune system, which is also known as the "cancer immune editing" theory. According to this theory, the immune system not only protects the host from tumor development, but also shapes the immunogenic phenotype of the developing tumor, thus promoting the formation or selection of less immunogenic tumor variants that are better suited to survive in an environment with an intact immune system. Thus, providing a mechanism for developing tumors to evade immunological detection and clearance, tumor immune editing is divided into three phases, referred to as clearance, homeostasis, and escape.
In the complex tumor microenvironment, immune cells play the role of shaping and promoting each other with cancer cells, therefore, revealing the molecular mechanism of the interaction between cancer cells and immune cells in the tumor microenvironment and jointly blocking the relevant pathways will help to improve the effectiveness of tumor immunotherapy. Carcinogenesis is the progressive acquisition of immune evasion and development of tumor cells under the pressure of immune surveillance at various stages. The immunological responses occurring at each stage of its progression need to be deepened and elucidated, and more studies are needed to confirm whether the tumor is predominantly immunostimulatory in the early stage and immunosuppressive in the middle and late stages, forming an immunosuppressive network. Alfa Oncology has established an innovative tumor microenvironment center technology platform and is developing several technologies aimed at studying the interactions between immune cells and tumor cells and their mechanisms on tumor metastasis, providing a theoretical basis for targeted therapies based on the interactions between immune cells and tumor cells.
The tumor microenvironment plays an important role in tumorigenesis, invasion and metastasis, and is also closely related to tumor drug resistance. Therefore, tumor microenvironment simulation and the study of related cell interactions are essential to solve the challenges of tumor therapy. In vitro simulation based on biochip technology has certain advantages over traditional tumor research methods. Firstly, biochip technology has the advantage of being highly integrated, which can realize the organic combination of different functional units and facilitate the online detection of various important metabolites in the tumor microenvironment. Secondly, the flexibility of chip design enables the application of various biocompatible materials, and the simulation of tumor microenvironment is closer to the actual situation of the body. In addition, the biochip can simulate the dynamic characteristics of the microenvironment in vitro, which provides the possibility of drug screening. Using this technology, the molecular mechanisms and signaling pathways of tumor cell-immune cell interactions can be studied in depth, providing theoretical guidance and basis for immunotherapy.
Animal models include spontaneous tumor animal models, induced tumor animal models, transplanted tumor animal models and human tumor xenograft tumor models. The establishment of tumor animal models can study the interaction between tumor cells and immune cells and its molecular mechanism of action, evaluate the efficacy of immunotherapy, and can be used as a model for anti-tumor drug screening.
Alfa Oncology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.