Solutions for Redox Metabolism in TME

Relying on the technology platform of the tumor microenvironment center, Alfa Oncology is committed to providing global collaborators with a full range of solutions and services to study redox metabolism in the tumor microenvironment (TME) to help you successfully achieve your research goals.

Introduction

The redox microenvironment of cells refers to the equilibrium state of cellular redox reactions, i.e. the equilibrium state of electron transfer. The redox homeostasis of the cell is altered when the cell is subjected to environmental influences or signal modulation, and when the oxidation-active/reduction-active substances are changed. Tumor tissues, cells, or microenvironment have an imbalance in redox status compared to normal tissues and cells. This may be related to many factors, such as mitochondrial dysfunction, oncogenic gene activation, abnormal oxidative metabolism and hypoxia / reoxygenation cycle. Or signaling pathways associated with tumorigenesis can directly or indirectly regulate the metabolism of reactive oxygen species. The imbalance of redox status in tumor tissues, cells or microenvironment is mainly manifested by abnormally high levels of reactive oxygen species (ROS) and oxidative stress.

Solutions

An increasing number of studies suggest that intervention strategies targeting redox regulatory mechanisms may inhibit tumor growth and eliminate tumor drug resistance. However, the molecular mechanisms underlying the occurrence and effects of redox imbalance in tumor tissues, cells, or microenvironment are still controversial. Alfa Oncology has established an innovative technology platform for the tumor microenvironment center and is developing a variety of technologies to provide high quality solutions and services to our global collaborators. Scientific experiments are designed to investigate the alterations in redox metabolism and oxidative stress in tumor tissues, cells or microenvironment and their regulatory mechanisms for potential therapeutic strategies to intervene using this biochemical property of tumors.

Key technologies

Metabolomics plays an important role in understanding the intricacies of biochemistry and biological systems. Alfa Oncology offers metabolomics technologies (Metabolomics) to study all metabolic intermediates, hormones, signaling molecules and secondary metabolites within a tumor cell, tissue or tumor microenvironment (TME) to reveal, qualitatively and quantitatively, the relationship between the metabolites therein and The relationship between redox homeostasis. Compared to genomics and proteomics, metabolomics provides a more direct way to detect the physiological state. In order to better sort out the key unresolved issues in redox metabolic processes in tumor cells, tissues or tumor microenvironment (TME).

As one of the world's leading companies in the field of tumor microenvironment (TME) research, Alfa Oncology is committed to supporting researchers in making groundbreaking scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. With years of experience in the field of TME, we are ready to provide reliable solutions and quality services to our customers. If you have any special needs or questions, please feel free to contact us for support from our experienced experts.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.