Experimental Tumor Animal Models for TME Research
Relying on the tumor microenvironment center technology platform, Alfa Oncology provides customized services for experimental tumor animal models for TME research, helping researchers successfully achieve their research goals.
Experimental tumor animal models are animal models that use carcinogenic factors to induce tumor development in animals under experimental conditions. The principle is to use exogenous carcinogenic factors to cause abnormal genetic characteristics of cells that exhibit abnormal growth and high proliferative activity to form tumors. Tumors are induced in animals by the use of physical, chemical and biological carcinogenic factors under experimental conditions. The most common chemical carcinogenic factors include benzo(a)pyrene, methylcholanthrene, benzidine, nitrosamines, aflatoxins, etc. Animal models of carcinogen induction allow us to study the progression of tumors and microenvironmental alterations to understand the many environmental attacks that people may face and to help discover effective treatments for the resulting cancers.
Based on the tumor microenvironment technology center platform, Alfa Oncology has established a suite of carcinogen-induced mouse models for a variety of tumor types, including hepatocellular, lung, cervical, and leukocyte, to meet the diverse needs of our clients. The application of this model allows for the study of changes in the microenvironment during tumorigenesis, as well as the evaluation of treatment effects. At Alfa Oncology, we are committed to providing you with the most efficient mouse models to save your valuable time and ensure data reliability. If you are interested in learning more about animal models or drug discovery services, please contact us for more information.
- In situ induction: The carcinogens are directly contacted with the target tissues or organs of animals to induce tumor development in those tissues or organs, and the contact methods can be through coating, perfusion, feeding or embedding.
- Ectopic induction: Tumors of the tissues or organs after contact with carcinogens are produced by burying the tissues or organs under the skin of the animal or another normal animal. Ectopic-induced tumors have the advantages of easy observation and material extraction.
- When conducting experiments, attention must be paid to the selection of appropriate carcinogenic methods, animal strains, carcinogens and their solvents, dose and route of administration, and observation time. The dose of carcinogens should ensure a high survival rate, a short induction period and a high frequency of tumor induction.
- Application method (skin tumor), transoral administration method (esophageal cancer, gastric cancer and colorectal cancer, etc.), injection method, tracheal injection method (lung cancer), threading method, burial method, etc.
- Rats, mice, dogs, etc.
- Polycyclic hydrocarbons, nitrosamines, azo, aflatoxins.
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- The model inducing factors and conditions can be artificially controlled, and the induced rate is much higher than the natural incidence rate.
- The method is often applied to verify the role of suspected carcinogenic factors and in tumor etiology and tumor prevention studies.
- Long induction time (3-5 months, or even 1-2 years).
Alfa Oncology is dedicated to supporting scientists in making groundbreaking scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. We have established the tumor microenvironment center technology platform with high performance scientific instruments and high value solutions to ensure high quality services that enable scientists to explore the mysteries of life at the tumor microenvironment level. Please let us know your project requirements and we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to contact us.