Spatial Metabolome in TME

Relying on the tumor microenvironment center technology platform, Alfa Cytology provides spatial metabolome detection and analysis services for TME research, helping researchers successfully achieve their research goals.


Metabolomics is the closest omics to phenotype and an important part of systems biology. The synthesis and accumulation of metabolites often have precise spatial distribution, and their physiological functions are often closely related to their spatial distribution in tissues and even single cells. Therefore, achieving high-resolution spatial and precise localization of the distribution of metabolites in tissues is crucial for elucidating the synthesis, accumulation and regulatory mechanisms of metabolites.

Spatial Metabolomics for tumors and microenvironments expands the metabolomic information of tumors and microenvironments to two-dimensional or even three-dimensional levels, and studies the spatial distribution of small metabolic molecules in tissue sections, which greatly expands the understanding of cognition of spatial composition, distribution and changes of metabolites in the tumor microenvironment. It also helps to understand processes such as early regulation of tumors, metabolic disturbances during inflammation and drug metabolism.


At Alfa Cytology, we have established a mature tumor microenvironment center technology platform, with a group of experienced tumor microenvironment research experts and mature technologies. For tumor and microenvironment-related research, we provide efficient spatial metabolome detection and analysis services to help you explore the spatial composition, distribution and changes of metabolites in the tumor microenvironment (TME), and learn more about metabolic reprogramming during tumor development or drug metabolism.

Experiment process

Experiment Process of Spatial Metabolome in TME -Alfa Cytology

Data analysis

Basic analysis
  • Metabolite identification
  • Spatial clustering
  • Differential metabolite analysis
  • Differential mass spectral peak library analysis
  • Relative abundance and spatial distribution
Advanced analytics
  • Spatial colocalization analysis
  • Metabolite ROC analysis
Customized analysis The content of customized analysis services can be negotiated and determined according to the needs of customers. Such as:
  • Differential feature analysis of clustered regions
  • Differential feature analysis of target area

Note: Our services list and analysis content are constantly being updated and improved, please contact us by email for more up-to-date and relevant information.

Deliver results

A detailed experimental report, including experimental preprocessing, experimental conditions, mass spectrometry imaging analysis process, HE and other staining results, etc.

Our technical features

  • No labeling required, in situ detection.
  • High spatial resolution: 5 μm (subcellular level).
  • High mass resolution and high sensitivity.
  • Detecting a variety of substances: ability to image and analyze target or non-target analytes.

Service process

Service process

Alfa Cytology is dedicated to supporting scientists in making groundbreaking scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. We have established the tumor microenvironment center technology platform with high performance scientific instruments and high value solutions to ensure high quality services that enable scientists to explore the mysteries of life at the tumor microenvironment level. Please let us know your project requirements and we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.


Alfa Cytology is a service provider specializing in tumor microenvironment research.

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