Inflammatory Disease Models for TME Research
Relying on the tumor microenvironment center technology platform, Alfa Oncology provides customized services for animal models of inflammatory diseases for TME research, helping researchers successfully achieve their research goals.
Introduction
Inflammation is the basic response to tissue damage and pathogen invasion. Cytokines secreted by leukocytes (e.g. IL-1, IL-6, TNF-α, etc.) play an important role in inflammatory diseases. The tumor microenvironment is generally a chronic inflammatory environment with massive infiltration of inflammation-associated cells. Among them, the diversity of inflammatory cells and inflammation-associated factors together with tumor cells and stromal cells constitute a complex regulatory network. In different stages of tumorigenesis and development, the same cell type or the same cytokine plays different and sometimes even opposite roles in tumor development. Therefore, many new anti-inflammatory drugs are developed by mechanisms that hit the signaling pathways that target the expression, secretion and inflammatory response of important cytokines. At the same time, inflammatory disease models are ideal tools for exploring tumor formation and development, as well as changes in the tumor microenvironment.
Services
At Alfa Oncology, we have established a mature tumor microenvironment center technology platform with a group of experienced tumor model customization experts and proven technologies designed to provide our global customers with efficient and validated tumor models for tumor and microenvironment research and antitumor drug discovery.
Alfa Oncology has broken down experimental and technical barriers and established dozens of animal models of inflammatory diseases according to international standards for our clients to study related mechanistic topics.
Information on the inflammatory disease models we offer:
| Inflammation Type | Cell Lines |
|---|---|
| Arthritis | Adjuvant-induced arthritis (AIA) in Lewis Rats |
| Adjuvant-induced arthritis in Wistar Rats (AIA) | |
| Type II collagen-induced arthritis in Lewis/Wistar/DBA-1 rats (CIA) | |
| Type II collagen-induced arthritis in monkeys (CIA) | |
| Multiple sclerosis (MS) | Experimental autoimmune encephalomyelitis (EAE) induced by MBP in rats |
| MOG-induced chronic experimental autoimmune encephalomyelitis (EAE) in mice | |
| PLP-induced recurrent experimental autoimmune encephalomyelitis (EAE) in mice | |
| Delayed onset allergic inflammation (DTH) | DNFB/Oxazolone/mBSA-induced delayed-onset allergic inflammation in mice |
| Liver injury | Acute liver injury/fibrosis and cirrhosis induced by CCl4 in rats and mice |
| Inflammatory response models | Allergic rhinitis induced by Ovalbumin in mice |
| Acute lung injury induced by LPS in rats and mice | |
| LPS-induced endotoxic shock in mice | |
| Metabolic diseases | Type II diabetes model in mice using db/db or ob/ob |
| Alcohol-induced fatty liver in rats | |
| Hyperlipidemia induced by high-fat diet in hamsters | |
| Colitis and inflammatory bowel disease (IBD) | DNBS induced colitis in rats |
| Colitis induced by DSS in C57BL/6 mice | |
| Acute/chronic colitis induced by Dextran sodium sulfate in mice | |
| Local inflammation | Local inflammation induced by Croton Oil/Arachidonic Acid/Xylene/Phorbol Ester in mice |
| Local inflammation induced by Carrageenan in rats | |
| Asthma | Citric acid/Capsaicin-induced asthma in guinea pigs |
| Other inflammatory diseases | Ovalbumin-induced asthma in rats and mice |
| Anti-DNP lgE induced passive allergic skin reaction (PCA) in rats and mice |
Note: Our services list is constantly being updated and improved, please contact us by email for more up-to-date and relevant information.
- Model species
- The weight and age of the animal are required or not
- Male and female requirements
- Specific plan for model construction
- Customers need to provide experimental materials (treatment drugs) and detailed experimental information, (experimental animal grouping, drug treatment dose and treatment time).
- Original photos of experiments
- Complete experimental report (including experimental materials, experimental steps, experimental results, etc.)
Service process
With extensive experience in various cancer models and expertise in tumor and microenvironment, Alfa Oncology is the ideal partner to support your oncology therapeutic research. We provide customers with stock model products, model customization, and joint R&D services to provide you with the best tumor models and look forward to meeting your precise needs. Please let us know your project requirements and we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to contact us.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.