Inflammatory Disease Models for TME Research

Relying on the tumor microenvironment center technology platform, Alfa Cytology provides customized services for animal models of inflammatory diseases for TME research, helping researchers successfully achieve their research goals.


Inflammation is the basic response to tissue damage and pathogen invasion. Cytokines secreted by leukocytes (e.g. IL-1, IL-6, TNF-α, etc.) play an important role in inflammatory diseases. The tumor microenvironment is generally a chronic inflammatory environment with massive infiltration of inflammation-associated cells. Among them, the diversity of inflammatory cells and inflammation-associated factors together with tumor cells and stromal cells constitute a complex regulatory network. In different stages of tumorigenesis and development, the same cell type or the same cytokine plays different and sometimes even opposite roles in tumor development. Therefore, many new anti-inflammatory drugs are developed by mechanisms that hit the signaling pathways that target the expression, secretion and inflammatory response of important cytokines. At the same time, inflammatory disease models are ideal tools for exploring tumor formation and development, as well as changes in the tumor microenvironment.


At Alfa Cytology, we have established a mature tumor microenvironment center technology platform with a group of experienced tumor model customization experts and proven technologies designed to provide our global customers with efficient and validated tumor models for tumor and microenvironment research and antitumor drug discovery.

Alfa Cytology has broken down experimental and technical barriers and established dozens of animal models of inflammatory diseases according to international standards for our clients to study related mechanistic topics.

Information on the inflammatory disease models we offer:

Inflammation Type Cell Lines
Arthritis Adjuvant-induced arthritis (AIA) in Lewis Rats
Adjuvant-induced arthritis in Wistar Rats (AIA)
Type II collagen-induced arthritis in Lewis/Wistar/DBA-1 rats (CIA)
Type II collagen-induced arthritis in monkeys (CIA)
Multiple sclerosis (MS) Experimental autoimmune encephalomyelitis (EAE) induced by MBP in rats
MOG-induced chronic experimental autoimmune encephalomyelitis (EAE) in mice
PLP-induced recurrent experimental autoimmune encephalomyelitis (EAE) in mice
Delayed onset allergic inflammation (DTH) DNFB/Oxazolone/mBSA-induced delayed-onset allergic inflammation in mice
Liver injury Acute liver injury/fibrosis and cirrhosis induced by CCl4 in rats and mice
Inflammatory response models Allergic rhinitis induced by Ovalbumin in mice
Acute lung injury induced by LPS in rats and mice
LPS-induced endotoxic shock in mice
Metabolic diseases Type II diabetes model in mice using db/db or ob/ob
Alcohol-induced fatty liver in rats
Hyperlipidemia induced by high-fat diet in hamsters
Colitis and inflammatory bowel disease (IBD) DNBS induced colitis in rats
Colitis induced by DSS in C57BL/6 mice
Acute/chronic colitis induced by Dextran sodium sulfate in mice
Local inflammation Local inflammation induced by Croton Oil/Arachidonic Acid/Xylene/Phorbol Ester in mice
Local inflammation induced by Carrageenan in rats
Asthma Citric acid/Capsaicin-induced asthma in guinea pigs
Other inflammatory diseases Ovalbumin-induced asthma in rats and mice
Anti-DNP lgE induced passive allergic skin reaction (PCA) in rats and mice

Note: Our services list is constantly being updated and improved, please contact us by email for more up-to-date and relevant information.

Information to be confirmed

  • Model species
  • The weight and age of the animal are required or not
  • Male and female requirements
  • Specific plan for model construction
  • Customers need to provide experimental materials (treatment drugs) and detailed experimental information, (experimental animal grouping, drug treatment dose and treatment time).

Delivery standard

  • Original photos of experiments
  • Complete experimental report (including experimental materials, experimental steps, experimental results, etc.)

Service process

Service process

With extensive experience in various cancer models and expertise in tumor and microenvironment, Alfa Cytology is the ideal partner to support your oncology therapeutic research. We provide customers with stock model products, model customization, and joint R&D services to provide you with the best tumor models and look forward to meeting your precise needs. Please let us know your project requirements and we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.


Alfa Cytology is a service provider specializing in tumor microenvironment research.

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