Solutions for Apoptosis and Tumor Progression
Relying on the technology platform of the tumor microenvironment center, Alfa Oncology provides global collaborators with solutions and services to study the relationship between apoptosis and tumor progression and its molecular mechanisms, helping researchers successfully achieve their research goals.
Apoptosis is a function of almost all cells of lower and higher animals, and it plays an extremely important role in the normal development and stability of the multicellular animal organism. Apoptosis, cell proliferation and differentiation are the basic life activities of cells, and they are closely related. The proliferation, differentiation and apoptosis of normal cells are strictly regulated by a complex sequence of genes. The imbalance between cell proliferation, differentiation and apoptosis is related to the development of tumor.
The development of tumor is a complex process with multiple genes, steps and stages. Apoptosis mainly plays a negative regulatory role in tumor development, which can stop the rapid growth of tumor cells. According to the current understanding of the regulatory mechanism of apoptosis, genes related to apoptosis can be broadly classified into two categories: pro-apoptotic genes and anti-apoptotic genes. When the activity of pro-apoptotic genes is inhibited and/or anti-apoptotic genes are activated, the cell cannot be apoptotic and survives for a long time. When combined with abnormally high expression of oncogenes and/or suppression of tumor suppressor gene activity, this may eventually lead to cellular carcinogenesis and tumor formation. At present, the apoptosis-related genes that are closely related to tumor development are p53 gene and bc-2 gene family, which have been studied in depth.
There is much evidence that the development of tumors is closely related to the disruption of apoptosis regulation. Apoptosis is involved in the initiation of cancer and plays a negative regulatory role in cancer development. In the pre-cancerous stage, cells are more sensitive to apoptosis and more easily cleared, which is a manifestation of the self-protective function of the organism. Apoptosis will certainly have a profound impact on the prevention and treatment of human tumors. However, many aspects remain to be elucidated, such as: when and how does apoptosis begin during cell development? Is there a switch point gene that activates apoptosis between mitosis and maturation? Is there a real killer gene in the organism? What are the signaling pathways through which apoptosis works? What is the relationship between apoptosis and aging and whether there is a survival gene?
Alfa Oncology has established an innovative tumor microenvironment center technology platform and is developing several technologies to help global collaborators explore the relationship between apoptosis and tumor progression and its molecular mechanism, how to regulate apoptosis to prevent stop tumor development, or develop anti-tumor drugs.
With the deepening of the research and understanding of apoptosis, the detection of tumor cell apoptosis has become an urgent need. At present, a variety of methods for the study of apoptosis and tumorigenesis have been widely used, mostly in vitro experiments or animal experiments. We provide our customers with tumorigenic experiments of human or murine tumor cells, and provide customers with related services such as tumor orthotopic implantation, tumor metastasis model construction, and induced tumor model construction. Various tumor and tumor metastasis animal models can be established according to the specific needs of customers, and tumor animals are grouped and treated differently. During the experiment, the weight of mice, tumor volume and weight, apoptosis detection, and pathological detection and analysis of tumors were tracked and recorded. Assist clients to study the mechanisms of apoptosis and tumor development, and seek new drugs to prevent and treat tumors.
Alfa Oncology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.