Solutions for the Interaction of TAM with Lymphoma Cells

Relying on the technology platform of the tumor microenvironment center, Alfa Cytology provides comprehensive solutions for study the interaction between TAMs and lymphoma cells in TME, helping researchers to successfully achieve their research goals.


Interaction between TAM and Lymphoma Cells in TME

As an important component of the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are involved in the biological behavior of tumor generation, proliferation, metastasis and drug resistance. In recent years, many studies have shown that extensive infiltration of tumor-associated macrophages (TAMs) is associated with poor prognosis in a variety of lymphomas. Although some mechanisms of action are not fully understood, TAMs have been shown to be able to participate in the interaction between the tumor microenvironment (TME) and lymphoma cells in multiple ways. Therefore, exploring the translational effect of peripheral blood mononuclear cells and TAM in patients with hematologic malignancies such as lymphoma and the effect of TAM on tumor cells can provide a basis for risk stratification of patients with hematologic malignancies such as lymphoma and provide directions and targets for the development of novel therapeutic tools.


Because TAM infiltration is closely related to the poor prognosis of hematologic malignancies such as lymphoma, we investigated the process of TAM transformation and its relationship with clinical characteristics, whether lymphoma cells can promote the transformation of human peripheral blood mononuclear cells into TAM, whether this source of TAM can promote the growth of lymphoma cells and thus accelerate the disease development, and whether the transformation of TAM is related to the clinical stage of the disease, IPI, gender, age and other factors. Whether TAM transformation is related to clinical stage, IPI, gender, age and other factors. A comprehensive understanding of the occurrence and mechanisms of these issues may help to explore potential prognostic indicators and targeted therapeutic options in the future.

Alfa Cytology has established an innovative tumor microenvironment central technology platform and is developing multiple technologies to study the interactions and mechanisms between tumor-associated macrophages (TAMs) and lymphoma cells in the TME. In order to provide new ideas for drug development and new targets for clinical tumor treatment.    

Key technologies

To further explore the complex mechanisms of interaction between cells and their microenvironment (cell-to-cell and even cell-to-extracellular matrix) in a three-dimensional state, Alfa Cytology provides a more reliable and convenient tool - 3D co-culture model. At the same time, it provides technical and service support for the study of the interactions between lymphoma cells and tumor-associated macrophages (TAM). The use of co-culture 3D models can also be extended to a wider range of research areas, including co-culture of endothelial cells or vascular cells with tumor cells to investigate the endothelial cells for tumor growth, or co-culture of immune cells with tumor cells to study the immune killing effect, or even co-culture of immune cells, tumor cells and endothelial cells in 3D to establish drug screening or tumor research models.

Alfa Cytology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.


Alfa Cytology is a service provider specializing in tumor microenvironment research.

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