Solutions for the Interaction of Tumor Cells with Exosomes
Relying on the technology platform of the tumor microenvironment center, Alfa Oncology provides comprehensive solutions the study of the interactions between tumor cells and exosomes, helping researchers to successfully achieve their research goals.
The tumor microenvironment (TME) and its messaging with tumor cells directly determine the malignancy of a tumor. Tumorigenesis, progression, metastasis and drug resistance are inseparable from the role of the stroma. Exosomes are extracellular matrix components that have been discovered in recent years to play a key role in cell-to-cell communication.
Under both physiological and pathological conditions, exosomes can be released by some cells in the form of cytosol, such as immune cells, stem cells, and tumor cells, and are widely distributed in peripheral blood, urine, saliva, ascites, breast milk, cerebrospinal fluid and other body fluids. Exosomes contain a large number of biologically active substances such as proteins, nucleic acids, lipids, viruses and prions. These components interact within the tumor microenvironment and play an important role in the development of tumors.
Tumor-delivered exosomes interact with stromal cells in the tumor microenvironment, for example, tumors can transport specific miRNAs and LncRNAs through exosomes, which in turn regulate the tumor microenvironment and promote multiple biological processes such as tumor metastasis and invasion. In addition, the various biological information contained in tumor exosomes may be used as biological markers for tumor diagnosis in early tumor diagnosis, with certain diagnostic and potential therapeutic uses.
Tumor cell-derived exosomes play an important role in promoting tumor invasion and metastasis by transporting a series of proteins and miRNAs components between cells. Clarification of the physiological functions of exosomes is essential to determine their role in tumors. Along with the increasing research on exosomes, it has enriched our understanding of the interactions between tumor cells and their mechanisms, and provided a theoretical basis for the study of tumorigenesis, development, diagnosis and new methods of treatment. As an important component of the tumor microenvironment, exosomes are likely to become another hot spot in tumor microenvironment research after cytokines. Alfa Oncology has established an innovative tumor microenvironment center technology platform, and is developing multiple technologies to study the interaction of exosomes with tumor cells and their mechanisms, as well as their role in tumor occurrence, development, metastasis, diagnosis and treatment It provides a theoretical basis for targeted therapy, and promotes tumor diagnosis and treatment and metastasis blockade.
The role of exosomes in tumors cannot be ignored, but it is not only limited to tumor research, but has now become a focus and hot spot for research in multiple disciplines. In-depth investigation of the function of exosomes in information transfer between tumor cells should find out who secretes exosomes, who takes up exosomes, and who may function, how they interact with tumors and microenvironment, and what are the functional mechanisms in vivo and ex vivo. Therefore, Alfa Oncology can provide a range of technical guidance by relying on its own Oncology Technology Center platform. First, the donor and acceptor of exosomes are identified through exosome extraction and identification; then, the results of next-generation sequencing are screened to find which molecules in exosomes function, such as DNA, mRNA, microRNA, lncRNA, circRNA and other substances. Again, the functional mechanism is explored in vivo and ex vivo by interfering / overexpressing the molecule for animal and cellular experiments, or the interaction study with other cells/molecules in the tumor microenvironment. Finally, return to the clinic and do clinical relevance analysis. We will establish a tumor diagnosis system with exosomes as targets, monitor treatment response, and develop new anti-tumor drugs and vaccines, etc., in order to promote tumor diagnosis and prevention.
Alfa Oncology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.