Solutions for the Interaction of Tumor Cells and Stromal Cells
Relying on the technology platform of the tumor microenvironment center, Alfa Oncology provides comprehensive solutions the study of the interactions between tumor stem cells and stromal cells, helping researchers to successfully achieve their research goals.
Tumor metastasis is closely related to the tumor microenvironment in which cancer cells live. Stromal cells are an important part of the tumor microenvironment (TME), including reticulocytes, fibroblasts, vascular endothelial cells, adipocytes, mesenchymal cells, macrophages, lymphocytes and other inflammatory cells.
Tumor invasion and metastasis are a series of complex, multi-step, multi-factor interactions among tumor cells, host and tumor microenvironment in a continuous process. This process involves many factors, such as the acquisition of metastatic ability of tumor cells themselves, the reduction of intercellular adhesion, the degradation and destruction of extracellular matrix (ECM) and basement membrane (BM) by cancer cells, cytoskeletal remodeling causing cell movement and migration, cytokine-induced organ-specific targeting of cancer cells, tumor vascular and lymphatic vessel generation, cancer cell escape apoptosis and immune killing, etc. In recent years, studies on the interaction between different stromal cells and tumor cells have led to the understanding that stromal cells and tumor cells cause tumor cell infiltration and metastasis through paracrine secretion of soluble factors or activation of secretory signaling pathways.
Tumor infiltration and metastasis are the most important biological features of malignant tumors and the primary factors causing death in cancer patients. Although great progress has been made in chemotherapy, radiotherapy, biotherapy and non-surgical combination therapy for tumors, the process of tumor infiltration and metastasis still cannot be stopped. Alfa Oncology has established an innovative tumor microenvironment center technology platform and is developing several technologies aimed at studying the interactions between different stromal cells and tumor cells and their mechanisms on tumor metastasis, providing a theoretical basis for targeted therapies based on the interactions between stromal cells and tumor cells.
Interactions between individual cells and adjacent cells determine the realization of cellular functions and cellular morphology. Understanding the mechanism of intercellular interactions is important for cell biology, especially in the fields of cancer therapy and stem cell regenerative medicine. Microfluidic technology can achieve single-cell manipulation at the order of magnitude, and has become one of the most promising single-cell analysis techniques in recent years. The application of microfluidic technology in single-cell pairing, fusion, migration, and cell-to-cell immune response is discussed, and the application prospects of microfluidic microarrays are prospected with organ-on-a-chip as an example.
Animal models include spontaneous tumor animal models, induced tumor animal models, transplanted tumor animal models and human tumor xenograft tumor models. The establishment of tumor animal models can study the interaction between tumor cells and stromal cells and its molecular mechanism of action, evaluate the efficacy of anti-tumor immunotherapy, and can be used as a model for anti-tumor drug screening.
Alfa Oncology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.