Solutions for Apoptosis and Tumor Therapy
Relying on the technology platform of the tumor microenvironment center, CD provides a full range of solutions and services to study topics related to apoptosis and tumor treatment, helping researchers successfully achieve their research goals.
Apoptosis is a function of almost all cells of lower and higher animals, and it plays an extremely important role in the normal development and stability of the multicellular animal organism. Apoptosis, cell proliferation and differentiation are the basic life activities of cells, and they are closely related. The proliferation, differentiation and apoptosis of normal cells are strictly regulated by a complex sequence of genes. The imbalance between cell proliferation, differentiation and apoptosis is related to the development of tumor.
The development of tumor is a complex process with multiple genes, steps and stages. Apoptosis mainly plays a negative regulatory role in tumor development, which can stop the rapid growth of tumor cells. According to the current understanding of the regulatory mechanism of apoptosis, genes related to apoptosis can be broadly classified into two categories: pro-apoptotic genes and anti-apoptotic genes. When the activity of pro-apoptotic genes is inhibited and/or anti-apoptotic genes are activated, the cell cannot be apoptotic and survives for a long time. When combined with abnormally high expression of oncogenes and/or suppression of tumor suppressor gene activity, this may eventually lead to cellular carcinogenesis and tumor formation. At present, the apoptosis-related genes that are closely related to tumor development are p53 gene and bc-2 gene family, which have been studied in depth.
In recent years, with the continuous research on the molecular regulation mechanism of apoptosis and the further elucidation of the relationship between apoptosis and tumor development, it has been gradually recognized that the induction of apoptosis is not only one of the mechanisms of the anti-tumor effects of radiotherapy, chemotherapy, thermotherapy and some biological therapies, but it can also be used as a new tumor treatment strategy by itself, and may form a new kind of apoptosis-inducing therapy. therapy. This therapy targets apoptosis-related genes / protein products in the apoptosis signaling pathway to intervene in tumor cell apoptosis imbalance. It mainly targets the targets of blocked apoptotic signaling pathway, increases the sensitivity of tumor cells to apoptosis induction by stimulating pro-apoptotic factors and/or inhibiting anti-apoptotic factors of tumor cells, restarts the cascade response of tumor cell apoptosis, and accelerates tumor cell apoptosis, so as to achieve the purpose of tumor therapy. Meanwhile, tumor cell apoptosis induction therapy can also be combined with other tumor therapies, and the combination of tumor cell proliferation inhibition, tumor cell differentiation induction and tumor cell apoptosis induction can be considered for different tumors to optimize the clinical treatment plan, which is expected to improve the tumor treatment effect.
Alfa Oncology has established an innovative tumor microenvironment center technology platform and is developing several technologies that aims to help global collaborators to study tumor treatment strategies by interfering with apoptosis.
Gene therapy. Combined genetic engineering means and in vitro experiments / animal experiments to induce apoptosis in tumor cells. By treating tumor cell lines, apoptosis was successfully induced to produce anti-tumor effects.
Hormones therapy. A variety of hormones induce apoptosis in tumor cells. For example, glucocorticoids induce apoptosis in human myeloid leukemia cells; androgens induce apoptosis in prostate cancer cells; progesterone is used to reduce the risk of ovarian cancer in postmenopausal women; progesterone induces apoptosis and inhibits the proliferation of ovarian cancer cells, while significantly upregulating the expression of p53.
Immunotherapy. Target cell death due to T cells, K cells, and NK cells, some of which are regulatory. When cytotoxic T lymphocyte (CTL) attack target cells, in addition to osmotic cytolysis, they secrete lymphotoxins that activate intracellular DNA endonucleases through target cell surface receptors, causing DNA breaks and apoptosis to occur. One of the important ways for immunoreactive cells, especially lymphokine-activated killer cells (LAK), to destroy tumor cells is also to induce apoptosis of target cells.
Alfa Oncology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.