Metastatic Tumor Models for TME Research

Relying on the tumor microenvironment center technology platform, Alfa Cytology provides customized services for metastatic tumor animal models for TME research, helping researchers successfully achieve their research goals.


Tumor metastasis is a continuous cascade process involving multiple factors, in which only a very small number of tumor cells survive in circulation and undergo lethal metastasis. The use of the human body itself as an experimental object to delve into the mechanisms of disease occurrence to advance medicine has been slow; the accumulated clinical experience is not only limited in time and space, but also many experiments are morally and methodologically restricted. Indirect studies with the help of animal models can observe the experimental results of models more accurately and conduct comparative studies with human diseases, which can help to understand the developmental patterns of human diseases more conveniently and effectively in order to study the prevention and control measures. It is a good research tool especially in tumor and microenvironment related studies.


Metastatic tumor animal models can provide a better research platform for tumor metastasis research, and also provide a good experimental tool for the study of the role of tumor microenvironment in tumor development and treatment, as well as the development of anti-tumor metastatic drugs.

At Alfa Cytology, we have established a mature tumor microenvironment center technology platform with a group of experienced tumor model customization experts and proven technologies designed to provide our global customers with efficient and validated tumor models for tumor and microenvironment research and antitumor drug discovery.

Alfa Cytology breaks down experimental and technical barriers to provide customization services for metastatic tumor animal models.

We offer two pathways for metastatic tumor animal models:

1. Metastasis in tumor animal models through in situ transplanted tumor cells.

2. Tumor cells are injected through multiple routes such as tail vein, portal vein, left ventricle, bone, spleen, and lymph nodes.

Information on the animal models of metastatic tumors we offer:

Tumor types Cell line Inoculate Metastasis
Melanoma B16 Intravenous Lung, Liver, Kidney, Heart
Liver Cancer HCCLM3 Liver Stomach, Lymph Nodes
Stomach Cancer MKN-45 Stomach Liver, Lymph Nodes
Bowel Cancer HT-29 Spleen Liver, Lymph Nodes
Bowel Cancer HCT-116 Cecum Liver, Lymph Nodes
Prostate Cancer PC-3 Intracardiac Bone
Lung Cancer A549 Intravenous Lung, Liver
Lung Cancer LL/2 Intravenous Lung
Breast Cancer 4T1 Breast pads Lung, Kidney

Note: Our services list is constantly being updated and improved, please contact us by email for more up-to-date and relevant information.

Information to be confirmed

  • Model species (rat or mouse or other species)
  • The weight and age of the animal are required or not
  • Male and female requirements
  • Specific plan for model construction
  • Customers need to provide experimental materials (treatment drugs) and detailed experimental information, (experimental animal grouping, drug treatment dose and treatment time).

Delivery standard

  • Original photos of experiments
  • Complete experimental report (including experimental materials, experimental steps, experimental results, etc.)

Service process

Service process

With extensive experience in various cancer models and expertise in tumor and microenvironment, Alfa Cytology is the ideal partner to support your oncology therapeutic research. We provide customers with stock model products, model customization, and joint R&D services to provide you with the best tumor models and look forward to meeting your precise needs. Please let us know your project requirements and we will provide you with a comprehensive service from solution to report. If you have any questions, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.


Alfa Cytology is a service provider specializing in tumor microenvironment research.

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