Therapeutic Strategies for Targeting Tumor Metabolism
Relying on the technology platform of the tumor microenvironment center, Alfa Oncology offers a full range of solutions and services or strategies for investigating therapeutic strategies that for target tumor metabolism, helping researchers successfully achieve their research goals.
During tumorigenesis, the entire metabolic network is reprogrammed under the dominance of proto-oncogenes and oncogenes and further shaped by the tumor microenvironment (TME). In turn, the flow and flux of nutrients through the tumor cell metabolic network is redefined to meet the material and energy requirements of tumor growth. This process, known as tumor cell metabolic reprogramming, facilitates biomolecule synthesis and achieves rapid and massive tumor cell proliferation. In recent years, antitumor therapies targeting tumor metabolism have received increasing attention from researchers, primarily to carry out an understanding of tumor metabolism and how to guide therapies that target the metabolic needs of tumor cells.
Does the plasticity of metabolic pathways allow tumours to rapidly switch adaptive mechanisms in the face of stress? How do tumor cells reprogramme their metabolism and that of other cells in the tumor microenvironment? How do they drive disease progression? These are among the questions that need to be addressed. Alfa Oncology has established an innovative tumor microenvironment center technology platform and is developing several technologies designed to help global collaborators develop therapeutic strategies that target tumor metabolism. Not only for the treatment of tumors, but also to provide guiding knowledge for their prevention and care.
Key strategies and technologies
Alfa Oncology has conducted specific studies based on the multiple strategies that have been proposed to target tumor metabolism, including but not limited to the following:
- Controlling the supply of glucose
- Inhibition of glucose transport
- Interfering glutamine metabolism
- Glycolytic pathway inhibitors
- Hypoxia-inducible factors
- Glucose mimetics
The technologies involved in the services provided by Alfa Oncology for research targeting tumor metabolism include, but are not limited to:
- Imaging technology
- Animal models
- Animal experiments
- Single cell sequencing in TME
- Spatial metabolomics
- Single cell metabolomics
Note: The key strategies and technologies we focus on are always up to date, please contact us by email for more up-to-date and relevant information.
Alfa Oncology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.