Solutions for TME and Tumor Angiogenesis
Relying on the technology platform of the tumor microenvironment center, Alfa Oncology provides comprehensive solutions for the study of TME and tumor angiogenesis, helping researchers successfully achieve their research goals.
The tumor microenvironment refers to the local complex environment (with characteristics such as hypoxia, glycolysis, low pH, relative lack of nutrients, and interstitial high pressure) in which tumors are located during the growth process, mainly including tumor cells, endothelial cells, immune cells, fibroblasts, pericytes and extracellular matrix, as well as soluble substances such as cytokines and peptide growth factors secreted by these cells. Tumor angiogenesis refers to the process in which the tumor microenvironment induces the formation of a capillary-based vascular system based on the original blood vessels, and establishes blood circulation in the tumor tissue.
When the tumor grows to 1-2 mm in diameter, it needs to establish an external tissue environment suitable for its own growth. At this time, cells in the microenvironment are in contact with each other, cytokines interact, and delicate and complex communication occurs between components. By inducing angiogenesis and other pathways, new nutrient metabolism networks are continuously constructed, thereby promoting further tumor growth.
Tumor angiogenesis is closely related to the tumor microenvironment and is regulated by a variety of pro-angiogenic factors and/or angiogenesis-inhibiting factors. There are many topics in current scientific research that start from various components of the tumor microenvironment, and study in detail the regulation of the tumor microenvironment on tumor angiogenesis. Many anti-tumor angiogenesis drugs have entered the clinic. Targeting the tumor microenvironment as an antivascular therapy has been shown to be effective. However, the tumor microenvironment is complex and variable, so many mechanisms remain unclear. Alfa Oncology is developing a variety of technologies to explore and study these issues in depth. It is believed that with the in-depth research on the tumor microenvironment, the development of multi-targeted drugs and the combined application of multi-targeted drugs will improve the effect of anti-tumor angiogenesis, thereby prolonging the survival of cancer patients.
As far as angiogenesis is concerned, two-dimensional cell culture cannot form a three-dimensional vascular system, so it is not suitable for the study of angiogenesis, collateral association and remodeling. To this end, we have started to establish a three-dimensional culture model (3D culture model) and successfully induced the formation of blood vessels from endothelial cells. Advances in the technique of culturing vascular endothelial cells in vitro and experimental methods of angiogenesis have promoted the research progress of angiogenesis. Since then, anti-angiogenic therapy has been aided in various aspects, such as attacking existing tumor blood vessels; neutralizing angiogenesis-promoting factors, thereby inhibiting angiogenesis; using endogenous or exogenous angiogenesis-inhibiting factors to inhibit angiogenesis.
There are a variety of imaging techniques that can be used to evaluate tumor angiogenesis. Each method has its own unique advantages and application scope, but all of them can non-invasively, rapidly, and evaluate tumor angiogenesis and anti-angiogenic efficacy in vivo. Through these technologies, more and better tumor vascular marker molecules are discovered, suitable targets are found to block and destroy tumor angiogenesis, and effective anti-tumor angiogenesis drugs are developed. It is used for early diagnosis, recurrence monitoring, clinical medication guidance and efficacy evaluation of tumors.
Alfa Oncology is committed to supporting scientists in making breakthrough scientific discoveries and developing new applications to accelerate new drug discovery and scientific diagnosis and treatment. Our high-performance scientific instruments and high-value solutions enable scientists to explore the mysteries of life at the tumor microenvironment level. Please tell us your project requirements, and we will provide you with a full service from solution to report. If you have any questions, please feel free to contact us.