Catalog No.: TME-PT01729
Product Details
Target Name | Integrin alpha 11 beta 1 |
Alternative Names | Integrin alpha 11 beta 1, ITGA11&ITGB1 |
Size | 100 μg, 1 mg (500 μg × 2) |
Species | Canine |
Tag | His Tag, Tag Free |
Host | Human 293 cells (HEK293) |
Conjugate | Unconjugated |
Sequence | AA Asp 21 - Pro 1142 (ITGA11) & Asp 23 - Asp 728 (ITGB1) |
Molecular Characterization | The protein we provide is produced by co-expression of ITGA1 and ITGB1, with a calculated MW of 132.6 kDa (ITGA11) and 83.2 kDa (ITGB1). Subunit ITGA1 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. |
Purity | >90% as determined by SDS-PAGE. |
Formulation | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.5 with trehalose as protectant. |
Storage | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
Endotoxin | Less than 1.0 EU per μg by the LAL method. |
Background | Integrin alpha 11 beta 1 serves as a receptor specifically for collagen. The genetic information (cDNA) for alpha11 encodes a mature protein with a substantial extracellular domain consisting of 1120 amino acids. This domain includes an I-domain composed of 207 amino acids. The extracellular domain iis linked by a transmembrane domain to a short cytoplasmic domain of 24 amino acids. The deduced alpha11 protein exhibits the characteristic structural traits of integrin alpha-subunits and shares similarities with a distinct group of alpha-subunits found in collagen-binding integrins. |
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