Product Details
| Target Name | Integrin alpha 1 beta 1 |
| Alternative Names | Integrin alpha 1 beta 1, ITGA1&ITGB1 |
| Size | 100 μg, 1 mg (500 μg × 2) |
| Species | Human / Mouse |
| Tag | His Tag, Tag Free |
| Verification Method | MALS verified |
| Host | Human 293 cells (HEK293) |
| Conjugate | Unconjugated |
| Sequence | AA Phe 29 - Pro1141 & Gln 21 - Asp 728 |
| Molecular Characterization | The protein we provide is produced by co-expression of ITGA1 and ITGB1, with a calculated MW of 130.0 kDa & 83.5 kDa. The protein migrates as 100-115 kDa and >180 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation. |
| Purity | >90% as determined by SDS-PAGE. |
| Formulation | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.5 with trehalose as protectant. |
| Storage | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
| Endotoxin | Less than 1.0 EU per μg by the LAL method. |
| Background | Integrin alpha-1/beta-1 is a receptor for laminin and collagen. The Integrin alpha-1/beta-1 and Integrin alpha-2/beta-1 integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. |
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