Catalog No.: TME-PT01734
Product Details
| Target Name | Integrin alpha 1 beta 1 |
| Alternative Names | Integrin alpha 1 beta 1, ITGA1&ITGB1 |
| Size | 100 μg, 1 mg |
| Species | Mouse |
| Tag | His Tag, Tag Free |
| Host | Human 293 cells (HEK293) |
| Conjugate | Unconjugated |
| Sequence | AA Phe 29 - Pro 1141 (ITGA1) & Gln 21 - Asp 728 (ITGB1) |
| Molecular Characterization | The protein we provide is produced by co-expression of ITGA1 and ITGB1, with a calculated MW of 130.0 kDa (ITGA1) and 83.5 kDa (ITGB1). Subunit ITGA1 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The reducing (R) protein migrates as 150-200 kDa (ITGA1) and 90-130 kDa (ITGB1) respectively due to glycosylation. |
| Purity | >90% as determined by SDS-PAGE. |
| Formulation | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.5. Normally trehalose is added as protectant before lyophilization. |
| Storage | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. |
| Endotoxin | Less than 1.0 EU per μg by the LAL method. |
| Background | Integrin alpha-1/beta-1 is a receptor that binds to both laminin and collagen. It plays a crucial role in supporting vascular endothelial growth factor signaling, facilitating endothelial cell migration, and promoting tumor angiogenesis. Specifically, it recognizes a collagen sequence that is proline-hydroxylated: G-F-P-G-E-R. Additionally, this integrin is involved in the regulation of cell growth stimulated by epidermal growth factor (EGF) in an anchorage-dependent manner, exerting a negative effect. |
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