Catalog No.: TME-PT01730
Product Details
| Target Name | Integrin alpha 11 beta 1 |
| Alternative Names | Integrin alpha 11 beta 1, ITGA11&ITGB1 |
| Size | 100 μg, 1 mg |
| Species | Mouse |
| Tag | His Tag, Tag Free |
| Host | Human 293 cells (HEK293) |
| Conjugate | Unconjugated |
| Sequence | AA Phe 23 - Pro 1141 (ITGA11) & Gln 21 - Asp 728 (ITGB1) |
| Molecular Characterization | The protein we provide is produced by co-expression of ITGA11 and ITGB1, with a calculated MW of 132.0 kDa (ITGA11) and 83.5 kDa (ITGB1). Subunit ITGA11 isfused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The reducing (R) protein migrates as 105-116 kDa and 150 kDa due to glycosylation. |
| Purity | >90% as determined by SDS-PAGE. |
| Formulation | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.5. Normally trehalose is added as protectant before lyophilization. |
| Storage | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. |
| Endotoxin | Less than 1.0 EU per μg by the LAL method. |
| Background | Integrin alpha 11 beta 1 serves as a receptor specifically for collagen. The genetic information (cDNA) for alpha11 encodes a mature protein with a substantial extracellular domain consisting of 1120 amino acids. This domain includes an I-domain composed of 207 amino acids. The extracellular domain iis linked by a transmembrane domain to a short cytoplasmic domain of 24 amino acids. The deduced alpha11 protein exhibits the characteristic structural traits of integrin alpha-subunits and shares similarities with a distinct group of alpha-subunits found in collagen-binding integrins. |
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