Product Details
| Size | 50 μL, 100 μL |
| Alternative Names | AGPT 2 antibody; Agpt2 antibody; ANG 2 antibody; ANG-2 antibody; ANG2 antibody; Angiopoietin 2a antibody; Angiopoietin 2B antibody; Angiopoietin-2 antibody; Angiopoietin2 antibody; ANGP2_HUMAN antibody; ANGPT 2 antibody; Angpt2 antibody; Tie2 ligand antibody |
| Target Name | ANGPT2 |
| Uniprot No. | O15123 |
| Raised In | Rabbit |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of Human ANGPT2 |
| Immunogen Species | Homo sapiens (Human) |
| Conjugate | Non-conjugated |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | Antigen affinity purification |
| Buffer | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Form | Liquid |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Application Suggestions
| Tested Applications | ELISA, WB, IHC |
| Recommended Dilution for ELISA | 1:2000-1:5000 |
| Recommended Dilution for WB | 1:500-1:2000 |
| Recommended Dilution for IHC | 1:50-1:200 |
Target Background
| Function (From Uniprot) | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
| Subcellular Location | Secreted. |
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