Catalog No.: TME-AB00041
Product Details
| Size | 50 μg, 100 μg |
| Alternative Names | Angpt2 antibody; Agpt2Angiopoietin-2 antibody; ANG-2 antibody |
| Target Name | ANGPT2 |
| Uniprot No. | O35608 |
| Raised In | Rabbit |
| Species Reactivity | Mouse |
| Immunogen | Recombinant Mouse Angiopoietin-2 protein (19-483AA) |
| Immunogen Species | Mus musculus (Mouse) |
| Conjugate | Biotin |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | >95%, Protein G purified |
| Buffer | Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01 M PBS, PH 7.4 |
| Form | Liquid |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Application Suggestions
| Tested Applications | ELISA |
Target Background
| Function (From Uniprot) | Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed only at sites of vascular remodeling. |
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