Catalog No.: TME-PT01725
Product Details
| Target Name | Integrin alpha 10 beta 1 |
| Alternative Names | Integrin alpha 10 beta 1, ITGA10&ITGB1 |
| Size | 100 μg, 1 mg |
| Species | Rat |
| Tag | His Tag, Tag Free |
| Host | CHO cells |
| Conjugate | Unconjugated |
| Sequence | AA Phe 23 - Ser 1162 (ITGA10) & Gln 21 - Asp 729 (ITGB1) |
| Molecular Characterization | The protein we provide has a calculated MW of 131.2 kDa | 83.7 kDa. |
| Storage | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
| Background | The recombinant form of human integrin alpha(10)I domain was used to investigate its binding specificity. It was observed that alpha(10)I recognized collagen types I-VI and laminin-1 in a Mg(2+)-dependent manner. However, its binding to tenascin was only slightly better than its binding to albumin. Alpha 10 beta 1 is an integrin known to bind collagen, along with other integrins such as α1β1, α2β1, and α11β1. Interestingly, the GROGER motif found in the N-terminal domain of collagens I and III was weakly recognized by α10β1, which is an important collagen receptor on chondrocytes. This behavior contrasts with the other collagen-binding integrins. |
| Note | Made-to-order |
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